48mer quinolinecarboxamide crystal structure

Want to know where the field of foldamers is going? Check this feature article in Chemistry World!

As the shape determines the function, chemists have designed and synthesized aliphatic and aromatic foldamers able to mimic protein-protein interactions, catalyze chemical reactions or encapsulate guest molecules in their cavity. Because of the diversity of sizes, shapes and arrangements available with non-natural building blocks, foldamers are versatile frameworks to access structural motifs and functions beyond those of peptides and nucleotides.


Royal Society of Chemistry, Rachel Brazil, 27.07.2020