Cover picture: Bioconjugate Chemistry, 2019, 30, 54

The paper focuses on the interactions between aromatic oligoamide foldamers and two therapeutically relevant proteins CypA and IL4. Several foldamers have been produced bearing a long or a short linker functionalized with an activated disulfide and tethered to cysteine residues introduced at the protein surfaces. The effective ligation was confirmed by CD, NMR and LC-MS techniques.